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Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

Vasohibin-1 (Vash1), originally isolated as an endothelium-derived angiogenesis inhibitor, has a characteristic of promoting stress tolerance in endothelial cells (ECs). We therefore speculated that the lack of the vash1 gene would result in a short lifespan. However, to our surprise, vash1(−/−) mic...

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Detalhes bibliográficos
Publicado no:J Aging Res
Main Authors: Takeda, Eichi, Suzuki, Yasuhiro, Yamada, Tetsuya, Katagiri, Hideki, Sato, Yasufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358453/
https://ncbi.nlm.nih.gov/pubmed/28367331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/9851380
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