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Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1
We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice. However, no effect on lifespan was observed in male Irs1 null mice. We suggested at the time that the lack of any ef...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2011
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026792/ https://ncbi.nlm.nih.gov/pubmed/21283571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016144 |
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