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Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan

Although extensively studied in C. elegans, no work has yet demonstrated for Drosophila melanogaster whether reduced insulin/IGF signaling (IIS) requires the FOXO transcription factor (foxo) to extend lifespan. Here we conduct genetic epistasis analysis to determine if foxo is required for chico mut...

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Bibliografski detalji
Glavni autori: Yamamoto, Rochele, Tatar, Marc
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135774/
https://ncbi.nlm.nih.gov/pubmed/21518241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00716.x
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