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Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan
Although extensively studied in C. elegans, no work has yet demonstrated for Drosophila melanogaster whether reduced insulin/IGF signaling (IIS) requires the FOXO transcription factor (foxo) to extend lifespan. Here we conduct genetic epistasis analysis to determine if foxo is required for chico mut...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135774/ https://ncbi.nlm.nih.gov/pubmed/21518241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00716.x |
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