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Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice. However, no effect on lifespan was observed in male Irs1 null mice. We suggested at the time that the lack of any ef...

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Bibliografiske detaljer
Main Authors: Selman, Colin, Partridge, Linda, Withers, Dominic J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026792/
https://ncbi.nlm.nih.gov/pubmed/21283571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016144
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