Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice

The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1(−/−)) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR signalling induces such effects is unclear,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Selman, Colin, Sinclair, Amy, Pedroni, Silvia M.A., Irvine, Elaine E., Michie, Alison M., Withers, Dominic J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2016
Gaiak:
Research Paper: Gerotarget (Focus on Aging)
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058654/
https://ncbi.nlm.nih.gov/pubmed/27083004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8729
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