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Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice
The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1(−/−)) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR signalling induces such effects is unclear,...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5058654/ https://ncbi.nlm.nih.gov/pubmed/27083004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8729 |
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