Small molecules facilitate rapid and synchronous iPSC generation

The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) upon overexpression of OCT4, KLF4, SOX2, and c-MYC (OKSM) provides a powerful system to interrogate basic mechanisms of cell fate change. However, iPSC formation with standard methods is protracted and inefficient, result...

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發表在:Nat Methods
Main Authors: Bar-Nur, Ori, Brumbaugh, Justin, Verheul, Cassandra, Apostolou, Effie, Pruteanu-Malinici, Iulian, Walsh, Ryan M., Ramaswamy, Sridhar, Hochedlinger, Konrad
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326224/
https://ncbi.nlm.nih.gov/pubmed/25262205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3142
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