Prospective Isolation of Rare Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming

Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). However, this process is typically very inefficient, complicating mechanistic studies. We identified and molecularly characterized rare, early intermediates poised to reprogram with up to 95% efficiency...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Schwarz, Benjamin A., Cetinbas, Murat, Clement, Kendell, Walsh, Ryan M., Cheloufi, Sihem, Gu, Hongcang, Langkabel, Jan, Kamiya, Akihide, Schorle, Hubert, Meissner, Alexander, Sadreyev, Ruslan I., Hochedlinger, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086589/
https://ncbi.nlm.nih.gov/pubmed/30017590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.06.013
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