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Lineage conversion induced by pluripotency factors involves transient passage through an iPS cell stage
Brief expression of pluripotency-associated factors such as Oct4, Klf4, Sox2 and c-Myc (OKSM), in combination with differentiation-inducing signals, was reported to trigger transdifferentiation of fibroblasts into other cell types. Here we show that OKSM expression in mouse fibroblasts gives rise to...
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| Publicado no: | Nat Biotechnol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4840929/ https://ncbi.nlm.nih.gov/pubmed/26098450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3247 |
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