HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization

The kinase PRKD2 (protein kinase D) is a crucial regulator of tumor cell-endothelial cell communication in gastrointestinal tumors and glioblastomas, but its mechanistic contributions to malignant development are not understood. Here, we report that the oncogenic chaperone HSP90 binds to and stabili...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Azoitei, Ninel, Diepold, Kristina, Brunner, Cornelia, Rouhi, Arefeh, Genze, Felicitas, Becher, Alexander, Kestler, Hans, van Lint, Johan, Chiosis, Gabriela, Koren, John, Fröhling, Stefan, Scholl, Claudia, Seufferlein, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315623/
https://ncbi.nlm.nih.gov/pubmed/25297628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1017
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