Large transcription units unify copy number variants and common fragile sites arising under replication stress

Copy number variants (CNVs) resulting from genomic deletions and duplications and common fragile sites (CFSs) seen as breaks on metaphase chromosomes are distinct forms of structural chromosome instability precipitated by replication inhibition. Although they share a common induction mechanism, it i...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Wilson, Thomas E., Arlt, Martin F., Park, So Hae, Rajendran, Sountharia, Paulsen, Michelle, Ljungman, Mats, Glover, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315293/
https://ncbi.nlm.nih.gov/pubmed/25373142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.177121.114
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