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Inhibition of Topoisomerase I prevents chromosome breakage at common fragile sites

Common fragile sites are loci that preferentially form gaps and breaks on metaphase chromosomes when DNA synthesis is perturbed, particularly after treatment with the DNA polymerase inhibitor, aphidicolin. We and others have identified several cell cycle checkpoint and DNA repair proteins that influ...

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Detalhes bibliográficos
Main Authors: Arlt, Martin F., Glover, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896008/
https://ncbi.nlm.nih.gov/pubmed/20413351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.03.005
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