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Inhibition of Topoisomerase I prevents chromosome breakage at common fragile sites
Common fragile sites are loci that preferentially form gaps and breaks on metaphase chromosomes when DNA synthesis is perturbed, particularly after treatment with the DNA polymerase inhibitor, aphidicolin. We and others have identified several cell cycle checkpoint and DNA repair proteins that influ...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896008/ https://ncbi.nlm.nih.gov/pubmed/20413351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.03.005 |
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