Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations. We analyzed 8% of PKC mutations identified in human cancers and found that, surprisingly, most were lo...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin J., Furnari, Frank B., Hunter, Tony, Brognard, John, Newton, Alexandra C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313737/
https://ncbi.nlm.nih.gov/pubmed/25619690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.001
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