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Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor
The discovery in the 1980s that protein kinase C (PKC) is a receptor for the tumor-promoting phorbol esters fueled the dogma that PKC is an oncoprotein. Yet 30+ years of clinical trials for cancer using PKC inhibitors not only failed, but in some instances worsened patient outcome. The recent analys...
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| Publicado no: | Trends Pharmacol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5403564/ https://ncbi.nlm.nih.gov/pubmed/28283201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2017.02.002 |
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