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PHLiPPing the Switch on Akt and Protein Kinase C Signaling

The Ser/Thr specific-phosphatase PHLPP (Pleckstrin Homology (PH) domain leucine-rich repeat protein phosphatase) provides “the brakes” for Akt and protein kinase C (PKC) signaling. The two isoforms of this recently discovered family, PHLPP1 and PHLPP2, control the amplitude and duration of signaling...

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Bibliographic Details
Main Authors: Brognard, John, Newton, Alexandra C.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963565/
https://ncbi.nlm.nih.gov/pubmed/18511290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2008.04.001
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