Common Polymorphism in the Phosphatase PHLPP2 Results in Reduced Regulation of Akt and Protein Kinase C

PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) terminates Akt and protein kinase C (PKC) activity by specifically dephosphorylating these kinases at a key regulatory site, the hydrophobic motif (Ser-473 in Akt1). Here we identify a polymorphism that results in an amino acid change from...

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Hlavní autoři: Brognard, John, Niederst, Matthew, Reyes, Gloria, Warfel, Noel, Newton, Alexandra C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685702/
https://ncbi.nlm.nih.gov/pubmed/19324870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901468200
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