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PHLiPPing the Switch on Akt and Protein Kinase C Signaling
The Ser/Thr specific-phosphatase PHLPP (Pleckstrin Homology (PH) domain leucine-rich repeat protein phosphatase) provides “the brakes” for Akt and protein kinase C (PKC) signaling. The two isoforms of this recently discovered family, PHLPP1 and PHLPP2, control the amplitude and duration of signaling...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963565/ https://ncbi.nlm.nih.gov/pubmed/18511290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2008.04.001 |
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