Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations. We analyzed 8% of PKC mutations identified in human cancers and found that, surprisingly, most were lo...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin J., Furnari, Frank B., Hunter, Tony, Brognard, John, Newton, Alexandra C.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313737/
https://ncbi.nlm.nih.gov/pubmed/25619690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.001
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