Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations. We analyzed 8% of PKC mutations identified in human cancers and found that, surprisingly, most were lo...

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Publicat a:Cell
Autors principals: Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin J., Furnari, Frank B., Hunter, Tony, Brognard, John, Newton, Alexandra C.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313737/
https://ncbi.nlm.nih.gov/pubmed/25619690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.001
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