A microfluidic method for synthesis of transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia

siRNA LOR-1284 targets the R2 subunit of ribonucleotide reductase (RRM2) and has shown promise in cancer therapy. In this study, transferrin (Tf) conjugated lipid nanoparticles (Tf-NP-LOR-1284) were synthesized by microfluidic hydrodynamic focusing (MHF) and evaluated for targeted delivery of LOR-12...

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Detalhes bibliográficos
Publicado no:Nanoscale
Main Authors: Yang, Zhaogang, Yu, Bo, Zhu, Jing, Huang, Xiaomeng, Xie, Jing, Xu, Songlin, Yang, Xiaojuan, Wang, Xinmei, Yung, Bryant C., Lee, L. James, Lee, Robert J., Teng, Lesheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312591/
https://ncbi.nlm.nih.gov/pubmed/25003978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4nr01510j
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