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Microfluidic hydrodynamic focusing synthesis of polymer-lipid nanoparticles for siRNA delivery

Small interfering RNAs (siRNAs) are promising as therapeutics for intractable diseases such as cancer. However, efficient and safe delivery of siRNAs in vivo remains a challenge. Polymer-lipid hybrid nanoparticles (P/LNPs) have been evaluated for therapeutic delivery of siRNA. In this study, a micro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Huang, Xueqin, Lee, Robert J., Qi, Yuhang, Li, Yujing, Lu, Jiahui, Meng, Qingfan, Teng, Lesheng, Xie, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722526/
https://ncbi.nlm.nih.gov/pubmed/29228574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18281
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