Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison

The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion is mediated by either G(q/11) proteins or βarrestin1 (βarr1), both of which can couple to its type 1 receptors (AT(1)Rs), present in adrenocortical zona glomerulosa (AZG) cell membranes. In the present study...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Dabul, Samalia, Bathgate-Siryk, Ashley, Valero, Thairy Reyes, Jafferjee, Malika, Sturchler, Emmanuel, McDonald, Patricia, Koch, Walter J., Lymperopoulos, Anastasios
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309955/
https://ncbi.nlm.nih.gov/pubmed/25631300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08116
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