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Angiotensin receptor blocker drugs and inhibition of adrenal beta-arrestin-1-dependent aldosterone production: Implications for heart failure therapy
Aldosterone mediates many of the physiological and pathophysiological/cardio-toxic effects of angiotensin II (AngII). Its synthesis and secretion from the zona glomerulosa cells of the adrenal cortex, elevated in chronic heart failure (HF), is induced by AngII type 1 receptors (AT(1)Rs). The AT(1)R...
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| Gepubliceerd in: | World J Cardiol |
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| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Baishideng Publishing Group Inc
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5368669/ https://ncbi.nlm.nih.gov/pubmed/28400916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4330/wjc.v9.i3.200 |
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