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The Extracellular Loop 2 (ECL2) of the Human Histamine H(4) Receptor Substantially Contributes to Ligand Binding and Constitutive Activity
In contrast to the corresponding mouse and rat orthologs, the human histamine H(4) receptor (hH(4)R) shows extraordinarily high constitutive activity. In the extracellular loop (ECL), replacement of F169 by V as in the mouse H(4)R significantly reduced constitutive activity. Stabilization of the ina...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4309601/ https://ncbi.nlm.nih.gov/pubmed/25629160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117185 |
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