Molecular determinants for the high constitutive activity of the human histamine H(4) receptor: functional studies on orthologues and mutants

BACKGROUND AND PURPOSE: Some histamine H(4) receptor ligands act as inverse agonists at the human H(4) receptor (hH(4)R), a receptor with exceptionally high constitutive activity, but as neutral antagonists or partial agonists at the constitutively inactive mouse H(4) receptor (mH(4)R) and rat H(4)...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Wifling, D, Löffel, K, Nordemann, U, Strasser, A, Bernhardt, G, Dove, S, Seifert, R, Buschauer, A
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301689/
https://ncbi.nlm.nih.gov/pubmed/24903527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12801
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