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Molecular determinants for the high constitutive activity of the human histamine H(4) receptor: functional studies on orthologues and mutants
BACKGROUND AND PURPOSE: Some histamine H(4) receptor ligands act as inverse agonists at the human H(4) receptor (hH(4)R), a receptor with exceptionally high constitutive activity, but as neutral antagonists or partial agonists at the constitutively inactive mouse H(4) receptor (mH(4)R) and rat H(4)...
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| 發表在: | Br J Pharmacol |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BlackWell Publishing Ltd
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301689/ https://ncbi.nlm.nih.gov/pubmed/24903527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12801 |
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