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The Extracellular Loop 2 (ECL2) of the Human Histamine H(4) Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

In contrast to the corresponding mouse and rat orthologs, the human histamine H(4) receptor (hH(4)R) shows extraordinarily high constitutive activity. In the extracellular loop (ECL), replacement of F169 by V as in the mouse H(4)R significantly reduced constitutive activity. Stabilization of the ina...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Wifling, David, Bernhardt, Günther, Dove, Stefan, Buschauer, Armin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309601/
https://ncbi.nlm.nih.gov/pubmed/25629160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117185
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