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The Extracellular Loop 2 (ECL2) of the Human Histamine H(4) Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

In contrast to the corresponding mouse and rat orthologs, the human histamine H(4) receptor (hH(4)R) shows extraordinarily high constitutive activity. In the extracellular loop (ECL), replacement of F169 by V as in the mouse H(4)R significantly reduced constitutive activity. Stabilization of the ina...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Wifling, David, Bernhardt, Günther, Dove, Stefan, Buschauer, Armin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309601/
https://ncbi.nlm.nih.gov/pubmed/25629160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117185
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