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The Extracellular Loop 2 (ECL2) of the Human Histamine H(4) Receptor Substantially Contributes to Ligand Binding and Constitutive Activity
In contrast to the corresponding mouse and rat orthologs, the human histamine H(4) receptor (hH(4)R) shows extraordinarily high constitutive activity. In the extracellular loop (ECL), replacement of F169 by V as in the mouse H(4)R significantly reduced constitutive activity. Stabilization of the ina...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4309601/ https://ncbi.nlm.nih.gov/pubmed/25629160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117185 |
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