Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H(4) Receptor Orthologs: Correlations and Discrepancies between Distal and Proximal Readouts

The investigation of the (patho)physiological role of the histamine H(4) receptor (H(4)R) and its validation as a possible drug target in translational animal models are compromised by distinct species-dependent discrepancies regarding potencies and receptor subtype selectivities of the pharmacologi...

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Detalhes bibliográficos
Main Authors: Nordemann, Uwe, Wifling, David, Schnell, David, Bernhardt, Günther, Stark, Holger, Seifert, Roland, Buschauer, Armin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759464/
https://ncbi.nlm.nih.gov/pubmed/24023919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073961
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