The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimer’s disease (AD). Aβ is generated from amyloid-β precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase. Inhibiting β-secretase activity is...

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Udgivet i:PLoS One
Main Authors: Hu, Jin, Lin, Ting, Gao, Yuehong, Xu, Junyue, Jiang, Chao, Wang, Guanghui, Bu, Guojun, Xu, Huaxi, Chen, Haifeng, Zhang, Yun-wu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309453/
https://ncbi.nlm.nih.gov/pubmed/25629409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115973
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