Učitavanje...
Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation
The β-site amyloid precursor protein (APP)-cleaving enzyme 1 (β-secretase, BACE1) initiates amyloidogenic processing of APP to generate amyloid β (Aβ), which is a hallmark of Alzheimer disease (AD) pathology. Cerebral levels of BACE1 are elevated in individuals with AD, but the molecular mechanisms...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937651/ https://ncbi.nlm.nih.gov/pubmed/24368770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532713 |
| Oznake: |
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