Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade

Rheb, a ubiquitous small GTPase, is well known to bind and activate mTOR, which augments protein synthesis. Inhibition of protein synthesis is also physiologically regulated. Thus, with cell stress the unfolded protein response system leads to phosphorylation of the initiation factor eIF2α and arres...

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Publicat a:Cell Rep
Autors principals: Tyagi, Richa, Shahani, Neelam, Gorgen, Lindsay, Ferretti, Max, Pryor, William, Chen, Po Yu, Swarnkar, Supriya, Worley, Paul F., Karbstein, Katrin, Snyder, Solomon H., Subramaniam, Srinivasa
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524804/
https://ncbi.nlm.nih.gov/pubmed/25660019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.014
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