Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia

L–DOPA–induced dyskinesia, the rate–limiting side–effect in the therapy of Parkinson’s Disease, is mediated by activation of mTOR signaling in the striatum. We show that Rhes, a striatal–specific protein, binds to and activates mTOR. Moreover, Rhes deleted mice manifest reduced striatal mTOR signali...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Subramaniam, Srinivasa, Napolitano, Francesco, Mealer, Robert G., Kim, Seyun, Errico, Francesco, Barrow, Roxanne, Shahani, Neelam, Tyagi, Richa, Snyder, Solomon H., Usiello, Alessandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267880/
https://ncbi.nlm.nih.gov/pubmed/22179112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2994
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