Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia

L–DOPA–induced dyskinesia, the rate–limiting side–effect in the therapy of Parkinson’s Disease, is mediated by activation of mTOR signaling in the striatum. We show that Rhes, a striatal–specific protein, binds to and activates mTOR. Moreover, Rhes deleted mice manifest reduced striatal mTOR signali...

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Detalhes bibliográficos
Main Authors: Subramaniam, Srinivasa, Napolitano, Francesco, Mealer, Robert G., Kim, Seyun, Errico, Francesco, Barrow, Roxanne, Shahani, Neelam, Tyagi, Richa, Snyder, Solomon H., Usiello, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267880/
https://ncbi.nlm.nih.gov/pubmed/22179112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2994
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