Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia

L–DOPA–induced dyskinesia, the rate–limiting side–effect in the therapy of Parkinson’s Disease, is mediated by activation of mTOR signaling in the striatum. We show that Rhes, a striatal–specific protein, binds to and activates mTOR. Moreover, Rhes deleted mice manifest reduced striatal mTOR signali...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Subramaniam, Srinivasa, Napolitano, Francesco, Mealer, Robert G., Kim, Seyun, Errico, Francesco, Barrow, Roxanne, Shahani, Neelam, Tyagi, Richa, Snyder, Solomon H., Usiello, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267880/
https://ncbi.nlm.nih.gov/pubmed/22179112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2994
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items