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Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity
Huntington's disease (HD) is caused by a polyglutamine repeat in the protein huntingtin (Htt) with mutant Htt (mHtt) expressed throughout the body and similarly in all brain regions. Yet, HD neuropathology is largely restricted to the corpus striatum. We report that the small guanine nucleotide...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745286/ https://ncbi.nlm.nih.gov/pubmed/19498170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172871 |
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