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Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH
The pathophysiology of Huntington’s disease reflects actions of mutant Huntingtin (Htt) (mHtt) protein with polyglutamine repeats, whose N-terminal fragment translocates to the nucleus to elicit neurotoxicity. We establish that the nuclear translocation and associated cytotoxicity of mHtt reflect a...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413934/ https://ncbi.nlm.nih.gov/pubmed/16492755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511316103 |
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