Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

Besides its role in glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) initiates a cell death cascade1–9. Diverse apoptotic stimuli activate inducible nitric oxide synthase (iNOS) or neuronal NOS (nNOS), with the generated nitric oxide (NO) S-nitrosylating GAPDH, abolishing its catalytic a...

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Hlavní autoři: Sen, Nilkantha, Hara, Makoto R., Kornberg, Michael D., Cascio, Matthew B., Bae, Byoung-Il, Shahani, Neelam, Thomas, Bobby, Dawson, Ted M., Dawson, Valina L., Snyder, Solomon H., Sawa, Akira
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689382/
https://ncbi.nlm.nih.gov/pubmed/18552833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1747
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