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Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis
Besides its role in glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) initiates a cell death cascade1–9. Diverse apoptotic stimuli activate inducible nitric oxide synthase (iNOS) or neuronal NOS (nNOS), with the generated nitric oxide (NO) S-nitrosylating GAPDH, abolishing its catalytic a...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2689382/ https://ncbi.nlm.nih.gov/pubmed/18552833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1747 |
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