Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH

The pathophysiology of Huntington’s disease reflects actions of mutant Huntingtin (Htt) (mHtt) protein with polyglutamine repeats, whose N-terminal fragment translocates to the nucleus to elicit neurotoxicity. We establish that the nuclear translocation and associated cytotoxicity of mHtt reflect a...

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Bibliografiske detaljer
Main Authors: Bae, Byoung-Il, Hara, Makoto R., Cascio, Matthew B., Wellington, Cheryl L., Hayden, Michael R., Ross, Christopher A., Ha, Hyo Chol, Li, Xiao-Jiang, Snyder, Solomon H., Sawa, Akira
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413934/
https://ncbi.nlm.nih.gov/pubmed/16492755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511316103
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