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Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade
Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the cytotoxic actions of cocaine reflect selective enhancement of autopha...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747760/ https://ncbi.nlm.nih.gov/pubmed/26787898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524860113 |
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