Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression

Presenilins (PS, PS1/PS2) are necessary for the proteolytic activity of γ-secretase, which cleaves multiple type I transmembrane proteins including Alzheimer's β-amyloid precursor protein (APP), Notch, ErbB4, etc. Cleavage by PS/γ-secretase releases the intracellular domain (ICD) of its substra...

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Bibliographic Details
Main Authors: Zhang, Yun-wu, Wang, Ruishan, Liu, Qiang, Zhang, Han, Liao, Francesca-Fang, Xu, Huaxi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888796/
https://ncbi.nlm.nih.gov/pubmed/17556541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703903104
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