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Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression
Presenilins (PS, PS1/PS2) are necessary for the proteolytic activity of γ-secretase, which cleaves multiple type I transmembrane proteins including Alzheimer's β-amyloid precursor protein (APP), Notch, ErbB4, etc. Cleavage by PS/γ-secretase releases the intracellular domain (ICD) of its substra...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1888796/ https://ncbi.nlm.nih.gov/pubmed/17556541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703903104 |
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