Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of β-Amyloid

β-Amyloid protein (Aβ), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from proteolytic cleavages of the amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and the γ-secretase complex. BACE1 is the rate-limiting enzyme for Aβ production, and...

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Detalhes bibliográficos
Main Authors: Chen, Yaomin, Huang, Xiumei, Zhang, Yun-wu, Rockenstein, Edward, Bu, Guojun, Golde, Todd E., Masliah, Eliezer, Xu, Huaxi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446780/
https://ncbi.nlm.nih.gov/pubmed/22895721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0757-12.2012
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