The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody

BACKGROUND: αKlotho is the prototypic member of the Klotho family and is most highly expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its actions include regulation of ion transport, cytoprotection, anti-oxidation and anti-fibrosis. In rodent models of chronic ki...

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Publicado en:Nephrol Dial Transplant
Main Authors: Barker, Sarah L., Pastor, Johanne, Carranza, Danielle, Quiñones, Henry, Griffith, Carolyn, Goetz, Regina, Mohammadi, Moosa, Ye, Jianfeng, Zhang, Jianning, Hu, Ming Chang, Kuro-o, Makoto, Moe, Orson W., Sidhu, Sachdev S.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309192/
https://ncbi.nlm.nih.gov/pubmed/25324355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfu291
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