The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody

BACKGROUND: αKlotho is the prototypic member of the Klotho family and is most highly expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its actions include regulation of ion transport, cytoprotection, anti-oxidation and anti-fibrosis. In rodent models of chronic ki...

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Dades bibliogràfiques
Publicat a:Nephrol Dial Transplant
Autors principals: Barker, Sarah L., Pastor, Johanne, Carranza, Danielle, Quiñones, Henry, Griffith, Carolyn, Goetz, Regina, Mohammadi, Moosa, Ye, Jianfeng, Zhang, Jianning, Hu, Ming Chang, Kuro-o, Makoto, Moe, Orson W., Sidhu, Sachdev S.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309192/
https://ncbi.nlm.nih.gov/pubmed/25324355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfu291
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