The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody

BACKGROUND: αKlotho is the prototypic member of the Klotho family and is most highly expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its actions include regulation of ion transport, cytoprotection, anti-oxidation and anti-fibrosis. In rodent models of chronic ki...

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Vydáno v:Nephrol Dial Transplant
Hlavní autoři: Barker, Sarah L., Pastor, Johanne, Carranza, Danielle, Quiñones, Henry, Griffith, Carolyn, Goetz, Regina, Mohammadi, Moosa, Ye, Jianfeng, Zhang, Jianning, Hu, Ming Chang, Kuro-o, Makoto, Moe, Orson W., Sidhu, Sachdev S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309192/
https://ncbi.nlm.nih.gov/pubmed/25324355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfu291
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