mTORC1 mediated translational elongation limits intestinal tumour initiation and growth

Inactivation of APC is a strongly predisposing event in the development of colorectal cancer(1,2), prompting us to search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth...

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Publicat a:Nature
Autors principals: Faller, William J., Jackson, Thomas J., Knight, John RP, Ridgway, Rachel A., Jamieson, Thomas, Karim, Saadia A., Jones, Carolyn, Radulescu, Sorina, Huels, David J., Myant, Kevin B., Dudek, Kate M., Casey, Helen A., Scopelliti, Alessandro, Cordero, Julia B., Vidal, Marcos, Pende, Mario, Ryazanov, Alexey G., Sonenberg, Nahum, Meyuhas, Oded, Hall, Michael N., Bushell, Martin, Willis, Anne E., Sansom, Owen J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304784/
https://ncbi.nlm.nih.gov/pubmed/25383520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13896
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