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Synthesis, HPLC Enantioresolution, and X-ray Analysis of a New Series of C5-methyl Pyridazines as N-Formyl Peptide Receptor (FPR) Agonists

The synthesis of three racemates and the corresponding non chiral analogues of a C5-methyl pyridazine series is described here, as well as the isolation of pure enantiomers and their absolute configuration assignment. In order to obtain optically active compounds, direct chromatographic methods of s...

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發表在:Chirality
Main Authors: Cilibrizzi, Agostino, Crocetti, Letizia, Giovannoni, Maria Paola, Graziano, Alessia, Vergelli, Claudia, Bartolucci, Gianluca, Soldani, Giacomo, Quinn, Mark T., Schepetkin, Igor A., Faggi, Cristina
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299864/
https://ncbi.nlm.nih.gov/pubmed/23744588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chir.22162
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