6-Methyl-2,4-Disubstituted Pyridazin-3(2H)-ones: A Novel Class of Small-Molecule Agonists for Formyl Peptide Receptors

Following a ligand-based drug design approach, a potent mixed formyl peptide receptor 1 (FPR1) and formyl peptide receptor-like 1 (FPRL1) agonist (14a) and a potent and specific FPRL1 agonist (14x) were identified. These compounds belong to a large series of pyridazin-3(2H)-one derivatives substitut...

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Detalhes bibliográficos
Main Authors: Cilibrizzi, Agostino, Quinn, Mark T., Kirpotina, Liliya N., Schepetkin, Igor A, Holderness, Jeff, Ye, Richard D., Rabiet, Marie-Josephe, Biancalani, Claudio, Cesari, Nicoletta, Graziano, Alessia, Vergelli, Claudia, Pieretti, Stefano, Piaz, Vittorio Dal, Giovannoni, Maria Paola
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888720/
https://ncbi.nlm.nih.gov/pubmed/19639995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900592h
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