Further Studies on 2-Arylacetamide Pyridazin-3(2H)-ones: Design, Synthesis and Evaluation of 4,6-Disubstituted Analogues as Formyl Peptide Receptors (FPRs) Agonists

Formyl peptide receptors (FPRs) play an essential role in the regulation of endogenous inflammation and immunity. In the present studies, a large series of pyridazin-3(2H)-one derivatives bearing an arylacetamide chain at position 2 was synthesized and tested for FPR agonist activity. The pyridazin-...

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Detalhes bibliográficos
Main Authors: Giovannoni, Maria Paola, Schepetkin, Igor A., Cilibrizzi, Agostino, Crocetti, Letizia, Khlebnikov, Andrei I., Dahlgren, Claes, Graziano, Alessia, Piaz, Vittorio Dal, Kirpotina, Liliya N., Zerbinati, Serena, Vergelli, Claudia, Quinn, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711119/
https://ncbi.nlm.nih.gov/pubmed/23685570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.03.066
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